AtrastiBio

Single-cell analysis

High-resolution biological analysis relies on the tools for micro-compartmentalization. While droplets transformed this field in the 2010s, our Semi-Permeable Compartment technology takes the next step.

SPC technology

Overcoming the limitations of droplets requires the means to easily control compartment contents. This is made possible by using hydrogel-based particles with selectively permeable shell.

Long-read sequencing

Our platform combines the versatility of multi-step sample preparation workflows with the power of next-generation long-read sequencing methodology.

SPC Technology

Semi-Permeable Compartments

The technology builds upon existing hydrogel-based isolation approaches to capture single cells or molecules. They key improvement is the ability to reliably generate core-shell topology particles.

Core/Shell particles topology ensures isolation of cells and nucleic acids, while being permeable to proteins and small molecules. Due to the liquid inner core, cell growth and molecular biology reactions can occur optimally in contrast to bulk hydrogel approaches.